Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1463 | CA3905 | U.S. | 1998 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 17 |
| 2 | DDI | 35 |
| 3 | Unknown | NA |
| 4 | 3TC+DDI+SQV | 78 |
| 5 | 3TC+D4T+IDV | 8 |
| 6 | 3TC+D4T+RTV | 4 |
| 7 | D4T+DDI+NFV | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I84V, L90M | Q58E, G73T | L10I, G17D, L63P, A71V, V77T, I93L |
| >CA3905| codons 1-99 PQITLWQRPIVTIKIGDQLKEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVREYD QIPIEICGHKVITTVLTGPTPVNVIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K70G, Q151M, M184V | A62V | Y181C | V35I, S68N, I135T, D177E, I178M, G196E, E203G, R211K, F214L, V245M, A272P, I293V, E297K | T253TA |
| >CA3904| codons 1-303 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTEMEKEGKISKIGPENPYNTPV FVIKKKDNTGWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSTNNETPGIRYQYNVLPMGWKGSPAIFQSSMTKILEPFRKQNPEMVI CQYVDDLYVGSDLEIEQHRTKIGELRQHLLKWGLTTPDKKHQKEPPFLWMGYELHPDKWT VQPIMLPEKDSWAVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVVPLTKEAE LEL |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |