<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
CA4771 CA39046 U.S. 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 DDI 61
2 3TC+AZT+IDV 202
3 D4T+EFV+RTV+SQV 87
4 3TC+ABC+AZT 81
5 D4T+DDI+LPV+TDF 44

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, L76V, V82A, L90M   L10I, T12P, Q18M, L63P, H69R, A71V, I72V, I85V, I93L  
>CA39046| codons 1-99
PQITLWQRPIVPIKIGGMLKEALLDTGADDTVLEEMNLPGRWKPKIIGGIGGFVKVRQYD
QIPIEICGRKVVGTVVVGPTPANIVGRNLMTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, K70KE, L210W, T215Y       V35T, T39A, K49R, K64KN, V90VI, V118VI, K122E, D123S, I135T, S162D, I178M, T200A, R211K, V245T, E248D, R284RK, I293V, E297K P59PR, S68SI
>CA39047| codons 1-299
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICAELEKEGKISRIGPENPYNTRV
FAINKKDITEWRKLVDFRELNKRTQDFWEIQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL
DESFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQDSMTKILEPFRKQNPDMVI
YQYMDDLYVGSDLEIGQHRAKIEELRQHLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT
VQPITLPDKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLKGTKALTEVVPLTKEA

References
Author Title Citation
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005