Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA16262 | CA38675 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 91 |
| 2 | D4T | 31 |
| 3 | 3TC+D4T | 65 |
| 4 | 3TC+D4T+NFV | 109 |
| 5 | ABC+D4T+NFV | 57 |
| 6 | 3TC+ABC+AZT+NFV | 136 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67HN, K70R, L74I, M184V, L210W, T215F | K219Q | A98G | V8VI, K20R, T39TAEK, V60I, T69N, K122E, I135T, S162SN, K166R, G196E, H208Y, R211K, D218E, A288S, I293IV |
| >CA38675| codons 1-300 PISPIETIPVKLKPGMDGPRVKQWPLTEEKIKALVEICKELEKEGKISKIGPENPYNTPI FAIKKKNSNRWRKIVDFRELNKRTQDFWEVQLGIPHPGGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQNSMTRILEPFRKQNPDIVI YQYVDDLYVGSDLEIEQHRTKIEELRQYLWKWGFFTPEQKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKSLTEVVPLTEEAE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| D30N | I13V, K14KR, E35D, M36V, N37S, K45Q, L63P, I64V, V77I |
| >CA38674| codons 1-99 PQITLWQRPLVTVRIGGQLKEALLDTGADNTVLEDVSLPGRWKPQMIGGIGGFIKVRQYD QIPVEICGHKAIGTVLIGPTPVNIIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |
| Rhee, SY | Predictive Value of HIV-1 Genotypic Resistance Test Interpretation Algorithms. | J Infect Dis, 2009 |