Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1441 | CA3852 | U.S. | 1998 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 122 |
| 2 | AZT+ DDI | 104 |
| 3 | 3TC+ DDI+ AZT | 61 |
| 4 | AZT+ DDI+ RTV | 26 |
| 5 | AZT+ DDI+ IDV+ NVP | 76 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A, L90M | Q58E | L10I, I15V, K20R, E35D, M36I, N37E, W42Y, K55R, R57K, I62V, L63P, A71V |
| >CA3852| codons 1-99 PQITLWQRPIVTIKVGGQLREALLDTGADDTVLEDIELPGRYKPKLIGGIGGFVRVKEYD QVPIEICGHKVIGTVLVGPTPANIIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, T215F | K219Q | K101E, Y181C, G190A | K20R, V35M, T39E, R83K, K104N, I202V, L228H |
| >CA3851| codons 1-237 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALMEICEEMEKEGKISKIGPENPYNTPV FAIKKKNSTRWRKLVDFRELNKKTQDFWEVQLGIPHPAGLEKKNSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI CQYMDDLYVASDLEIGQHRTKVEELRQHLLRWGFFTPDQKHQKEPPFHWMGYELHPD |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |