Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA16163 | CA38464 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | Unknown | 52 |
| 2 | 3TC+AZT+RTV+SQV | 28 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48V, I54ST, V82A | L33LF, Q58E | L10I, I13IV, K14KR, I15V, K20KR, E35D, M36I, N37D, D60E, Q61E, L63P, A71V, I93L |
| >CA38464| codons 1-99 PQITLWQRPIVTVRVGGQLREALLDTGADDTVFEDIDLPGRWKPKMIVGIGGFTKVREYE EIPIEICGHKVIGTVLVGPTPANIIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M184V | V35R, T39TA, A98S, I135T, D177E, I178ILM, T200TA, E204A, R211Q, F214L, E248D, I257IM, V261VI, A272P, K281R, L283I, T286A, I293V, P313S, V317A, Q334L, M357T, G359S, K390R, A400T, V435A, E449D, L452A, T477A, H483N, K512T, V531I, Q547R, A554S |
| >CA38465| codons 1-560 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALREICAEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPSGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEMVI YQYVDDLYVGSDLEIGQHRAKIEALRQHLLQWGLTTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPDKDSWTVNDMQKLIGKLNWASQIYPGIKVKQLCRLIRGAKALTEVVPLTEEAE LELAENREILKESVHGAYYDPSKDLIAEIQKQGLGQWTYQIYQEPFKNLKTGKYARTRSA HTNDVKQLTEAVQKIATESIVIWGKTPKFRLPIQKETWETWWTEYWQATWIPEWEFVNTP PLVKLWYQLEKEPIAGAETFYVDGAANRDTKAGKAGYVTDRGRQKVVSLTDTTNQKAELQ AINLALQDSGLEVNIVTDSQYALGIIQAQPDTSESELVSQIIEQLIKKEKIYLAWVPAHK GIGGNERVDKLVSSGIRKVL |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |