Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1620 | CA38463 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 130 |
| 2 | NRTI | 286 |
| 3 | D4T+ 3TC | 56 |
| 4 | IDV+ NVP+ 3TC | 60 |
| 5 | None | 45 |
| 6 | SQV+ RTV+ NVP+ AZT+ 3TC | 19 |
| 7 | EFV+ ABC+ 3TC | 62 |
| 8 | None | 11 |
| 9 | D4T+ APV+ 3TC+ LPV | 6 |
| 10 | None | 80 |
| 11 | 3TC+ ABC+ AZT+ LPV | 3 |
| 12 | 3TC+ AZT+ LPV | 25 |
| 13 | 3TC+ DDI+ TDF | 21 |
| 14 | 3TC+ DDI+ EFV+ TDF | 5 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74V, M184V, T215Y | G190S | T39D, V118VI, A158S, S162C, V189I, V276VI, R284K, T286A, V292I, I293V, E297A |
| >CA38463| codons 1-304 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICDELEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPSIFQCSMTKILEPFRKQNPDIVI YQYVDDLYISSDLEIGQHRTKIEELRQHLLRWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKIKQLCKLLKGAKALTEIVPLTAEAE LELA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L63P |
| >CA38462| codons 1-99 PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVRQYD QIPIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |