Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA4042 | CA38425 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+ DDC | 104 |
| 2 | D4T | 104 |
| 3 | 3TC+ AZT+ RTV+ SQV | 52 |
| 4 | 3TC+ AZT+ EFV+ RTV+ SQV | 52 |
| 5 | 3TC+ D4T+ IDV+ NVP | 62 |
| 6 | 3TC+ ABC+ APV+ AZT | 41 |
| 7 | 3TC+ AZT+ IDV+ RTV | 52 |
| 8 | 3TC+ DLV+ T20+ TDF | 117 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67DN, L74LV, L210W, T215Y | K219KNRS | Y188YFHL, P236PL | K101H, K238KT | T27S, E28EA, K43E, E44EA, K49KR, V118I, K122E, I142IV, S162C, E169D, I178L, H208HY, R211K, L228H, A272P |
| >CA38425| codons 1-274 PISPIETVPVKLKPGMDGPKVKQWPLSAEKIKALVEICTELEEAGKISRIGPENPYNTPV FAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLHKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQCSMTKILDPFRKQNPDLVI YQYMDDLLVGSDLEIGQHRTKIEELRQYLWKWGFYTPDSKHQKEPPFHWMGYELHLDTWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGI |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| N37S, I62V, L63P, V77I, I93L |
| >CA38424| codons 1-99 PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGRWKPKMIGGIGGFIKVRQYD QVPIEICGHKAIGTVLIGPTPVNIIGRNLLTQLGCTLNF |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |
| Melikian, GL | Standardized comparison of the relative impacts of HIV-1 reverse transcriptase (RT) mutations on nucleoside RT inhibitor susceptibility. | AAC, 2012 |