Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1432 | CA3831 | U.S. | 1998 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 208 |
| 2 | 3TC+AZT+IDV | 161 |
| 3 | D4T+DDI+SQV | 7 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, V82T, L90M | L10I, T12P, K14R, Q61E, L63P, C67S, A71T, V77I, I93L, C95F |
| >CA3831| codons 1-99 PQITLWQRPIVPIRIGGQLKEALLDTGADDTVLEEMNLPGRWKPKLIGGIGGFIKVRQYD EIPIEISGHKTIGTVLIGPTPTNIIGRNLMTQLGFTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67NT, K70R, M184V, L210W, T215Y | K219E | K20R, I31IL, V35I, T39A, V60I, K64KR, K122E, S134SR, I135T, Q174K, Q207E, R211K, L228H |
| >CA3830| codons 1-278 PISPIETVPVKLKPGMDGPRVKQWPLTEEKLKALIEICAELEKEGKISKIGPENPYNTPI FAIRKKTSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPRTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKKNPDIVI YQYVDDLYVGSDLEIGQHRTKIEELREHLWKWGFYTPDEKHQKEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQ |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Wu, TD | Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. | J Virol, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |