Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1431 | CA3829 | U.S. | 1998 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+DDI | 182 |
| 2 | 3TC+AZT+SQV | 57 |
| 3 | D4T+NFV+NVP | 34 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, L90M | L10F, I84L | E35D, M36V, N37E, I62V, L63P, I64L |
| >CA3829| codons 1-99 PQITLWQRPFVTIKIGGQLKEALLDTGADDTVLEDVELPGRWKPKLIGGIGGFIKVRQYD QVPLEICGHKAIGTVLVGPTPVNLIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L210W, T215Y | K103KN, Y181YC, G190GA | K43E, V118I, I135V, I142V, K166R, R211K, H221HY, L228LI, V245M |
| >CA3828| codons 1-267 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEEEGKISKIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSIPL DKDFRKYTAFTIPSVNNETPGVRYQYNVLPQGWKGSPAIFQSSMTRILEPFRKQNPDIVI CQYMDDLYVASDLEIGQHRTKIEELRQHLWKWGFYTPDKKYQKEPPFIWMGYELHPDKWT VQPIMLPEKDSWTVNDIQKLVGKLNWA |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |
| Rhee, SY | Predictive Value of HIV-1 Genotypic Resistance Test Interpretation Algorithms. | J Infect Dis, 2009 |