Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA14547 | CA38274 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 34 |
| 2 | AZT+DDC | 17 |
| 3 | AZT | 47 |
| 4 | 3TC+AZT | 13 |
| 5 | 3TC+AZT+IDV | 69 |
| 6 | AZT+NFV+NVP | 8 |
| 7 | D4T+DDI+NFV+NVP | 47 |
| 8 | 3TC+AZT+EFV+NFV | 26 |
| 9 | ABC+AZT+DDI+RTV+SQV | 17 |
| 10 | ABC+APV+D4T+NVP | 95 |
| 11 | AZT+3TC+IDV | 8 |
| 12 | 3TC+APV+AZT+EFV | 26 |
| 13 | 3TC+AZT+NFV+NVP+TDF | 30 |
| 14 | None | 37 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46L, I54V, V82VA | L10F, K43KT | I15V, N37HR, R41RK, L63P, A71V, I85V |
| >CA38274| codons 1-99 PQITLWQRPFVTIKVGGQLKEALLDTGADDTILEEMRLPGKWTPKLIGGIGGFVKVRQYD QIPIEICGHKVIGTVLVGPTPANIVGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, L74V, M184MV, L210W, T215Y | K219R | K101E, Y181V, G190A | A98G, V108I | T39A, E44D, V106I, V118I, V179IM, E203K, H208Y, R211D, K223Q, A272P, K277R, I293V, E297K | I159L |
| >CA38275| codons 1-300 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICAELEKDGKISKIGPENPYNTPV FAIKKKNSDKWRKVVDFRELNKRTQDFWEVQLGIPHPGGLEKKKSITILDVGDAYFSIPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPALFQSSMTKILEPFRKQNPDIMI VQYVDDLYVASDLEIGQHRTKIKELRQYLWDWGFYTPDRKHQQEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVVPLTKEAE |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |