Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA14311 | CA38216 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | DDI | 169 |
| 2 | 3TC+D4T+NVP | 96 |
| 3 | 3TC+APV+D4T | 130 |
| 4 | 3TC+APV+D4T+DDC | 43 |
| 5 | 3TC+APV+D4T+DDC+RTV | 22 |
| 6 | 3TC+APV+D4T+DDC | 28 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54ILM, I84V, L90M | G73T, L89V | I13IV, L19Q, K20IM, L33LV, R57RK, I62V, L63P |
| >CA38216| codons 1-99 PQITLWQRPLVTVKIGGQQMEALLDTGADDTVVEEMNLPGRWKPKIIGGIGGFMKVKQYD QVPIEICGHKAITTVLVGPTPVNVIGRNVMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| T69D, K70R, M184V, T215F | D67G, K219Q | Y181C, G190A | E6D, S68G, K101Q, K102R, K122E, I135T, I142V, K173KR, Q207R, R211Q, D218E, L228H, R284K, I293V, E297V |
| >CA38217| codons 1-300 PISPIDTVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKGGDRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLQRKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSTNNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRRQNPDIVI CQYVDDLYVASDLEIGQHRTKIEELRRHLLQWGFFTPEQKHQKEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLKGTKALTEVVPLTVEAE |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |