Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA14219 | CA38197 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 48 |
| 2 | 3TC+AZT | 26 |
| 3 | 3TC+AZT+IDV | 113 |
| 4 | 3TC+AZT+NFV | 183 |
| 5 | D4T+DDI+EFV | 74 |
| 6 | 3TC+D4T+DDI+EFV+TDF | 7 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, L74V, M184V, T215Y | L100I, K103N | I135T, T200A, E203V, Q207E, L210F, R211K, P243S, V245E, A272S, T286A, I293V, E297K |
| >CA38197| codons 1-301 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV FAIKKKNSDKWRKVVDFRELNKRTQDFWEVQLGIPHPAGIKKNKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRAKIVELREHLFKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQSIELPEKDSWTVNDIQKLVGKLNWASQIYSGIKVKQLCKLLRGAKALTEVVPLTKEAE L |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A | L24I | L10V, T12P, I15V, G16E, L19I, K20M, M36I, R41K, I62V, L63Q, I64V, T74S |
| >CA38196| codons 1-99 PQITLWQRPVVPIKVEGQIMEALIDTGADDTVLEEINLPGKWKPKLIGGIGGFVKVRQYD QVQVEICGHKAIGSVLVGPTPANIIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |
| Rhee, SY | Predictive Value of HIV-1 Genotypic Resistance Test Interpretation Algorithms. | J Infect Dis, 2009 |