<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
CA2095 CA38150 U.S. 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 AZT 44
2 AZT+ DDI 21
3 AZT+ DDC+ SQV 22
4 AZT+ DDC+ RTV 25
5 3TC+ AZT+ IDV 31
6 3TC+ AZT+ NVP 1
7 3TC+AZT+RTV+SQV 58
8 D4T+DDI+EFV+Unknown 34
9 APV+D4T+DDC+EFV+SQV 6
10 APV+D4T+DDI+EFV+NFV 65
11 APV+D4T+DDI+EFV+LPV 79
12 Unknown 58

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I50V, I54V, V82A, L90M L33F, F53L L10I, I13V, K20R, E35D, M36I, N37S, R41K, R57RK, D60E, I62V, L63P, A71V  
>CA38150| codons 1-99
PQITLWQRPIVTVKIGGQLREALLDTGADDTVFEDISLPGKWKPKIIGGVGGLVKVKQYE
QVPIEICGHKVIGTVLVGPTPANIIGRNLMTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, K65R, Q151M, L210W A62V, V75I, F116Y, T215D G190S   K43Q, S68R, W88S, K101Q, V118I, K122E, R172K, I202V, F214L, E248D, K281R, A288S, I293V, E297K  
>CA38151| codons 1-300
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEQEGKISKIGPENPYNTPV
FVIKRKDRTKWRKLIDFRELNKRTQDFSEVQLGIPHPAGLQKKKSVTVLDVGDAYYSIPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPMGWKGSPAIFQSSMTKILEPFKKQNPDIVI
YQYMDDLYVSSDLEIGQHRTKVEELRQHLWRWGLDTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPDKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCRLLRGTKSLTEVVPLTKEAE

References
Author Title Citation
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005