Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA790 | CA38140 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 365 |
| 2 | AZT+DDC | 22 |
| 3 | 3TC+AZT | 31 |
| 4 | 3TC+AZT+IDV | 9 |
| 5 | 3TC+D4T+IDV | 60 |
| 6 | D4T+DDI+RTV+SQV | 58 |
| 7 | D4T+DDI+EFV+RTV+SQV | 28 |
| 8 | D4T+DDI+EFV+SQV | 18 |
| 9 | Unknown | 207 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54IV, I84IV | L10F, L24I, L33LF, G73S | I13V, L19LI, L63P, I66V, I72MV, P79AD, I93L |
| >CA38140| codons 1-99 PQITLWQRPFVTVKIGGQIKEALIDTGADDTVFEEMNLPGRWKPKIIGGIGGFVKVRQYD QIPIEVCGHKAVSTVLVGDTPVNVIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, T215Y | K219Q | Y181YC, G190GRS | V35I, T39A, K49R, K70X, K101Q, V106VI, K122E, D123E, I135T, V179VI, D218E, D237E, E248D, I293V, E297A |
| >CA38141| codons 1-301 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICAELEKEGKISRIGPENPYNTPV FAIKKKNSTXWRKVVDFRELNKRTQDFWEVQLGIPHPAGLQKKKSITVLDVGDAYFSVPL DEEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIII CQYMDDLYVSSDLEIGQHRTKIEELRQHLLRWGFYTPEQKHQKEPPFLWMGYELHPEKWT VQPIVLPDKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVVPLTAEAE L |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |