Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1498 | CA38126 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | D4T | 61 |
| 2 | AZT | 44 |
| 3 | 3TC+AZT+SQV | 82 |
| 4 | 3TC+AZT | 6 |
| 5 | 3TC+AZT+IDV | 42 |
| 6 | D4T+NFV+NVP | 38 |
| 7 | 3TC+DDI+SQV | 145 |
| 8 | 3TC+LPV+SQV+TDF | 30 |
| 9 | 3TC+APV+LPV+TDF | 30 |
| 10 | 3TC+LPV+TDF | 2 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46MI, I54V, I84V, L90M | V11I, L33LF, G73S, L89LV | L10I, I13V, I15V, K20T, I62V, L63P, A71V, I72L, P79AS |
| >CA38126| codons 1-99 PQITLWQRPIITVKVGGQLTEALLDTGADDTVFEEMNLPGRWKPKIIGGIGGFVKVRQYD QVPIEICGHKVLSTVLVGSTPVNVIGRNVMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M184V, L210W, T215Y | K219E | Y181C | K101KHNQ | E6K, E28A, K122E, S162C, E169D, Q174QR, Q197E, E203EK, Q207E, R211K, L228H, A272P, K277R, T286A, A288S, E297T, E300D |
| >CA38127| codons 1-300 PISPIKTVPVKLKPGMDGPKVKQWPLTAEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLQKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILDPFRKRNPDIVI CQYVDDLYVGSDLEIGEHRTKIKELREHLWKWGFYTPDEKHQKEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKSLTEVIPLTTEAD |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |