<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
CH001546 CA38115 U.S. 1999 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 DDI 61
2 AZT+DDI+SQV 26
3 3TC+AZT+SQV 26
4 3TC+AZT+NFV 48
5 3TC+ABC+NVP 51

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
D67N, T69D, K70R, T215F K219Q G190A   K20R, K102R, K103R, K104KR, K122KE, D123DE, V179I, G196E, T200A, H208HY  
>CA38115| codons 1-249
PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKNSDRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKRRRSVTVLDVGDAYFSVPL
DEEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIII
YQYMDDLYVASDLEIEQHRAKIEELRQYLLRWGFFTPDQKHQKEPPFLWMGYELHPDKWT
VQPIVLPEK

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
L90M L10LF R41K, D60DE, I62V, L63AT, V77VI, I85IV  
>CA38114| codons 1-98
PQITLWQRPFVTIKIGGQLKEALLDTGADDTVLEEMNLPGKWKPKMIGGIGGFIKVRQYE
QVTIEICGHKAIGTVLIGPTPVNIVGRNLMTQIGCTLN

References
Author Title Citation
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005