<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
CA2204 CA38109 U.S. 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 AZT+DDI 100
2 AZT+DDI+NFV 39
3 3TC+D4T+NVP 87
4 3TC+D4T+IDV 72
5 3TC+ABC+APV+D4T 37
6 APV+D4T+DDI+RTV 43
7 3TC+APV+D4T+RTV+TDF 18
8 3TC+ABC+AZT+EFV+TDF 70

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, L74I, M184V, L210W, T215Y   K101P, K103N, G190A   V35M, K43Q, E44D, D86N, V118I, E138Q, S162D, G196E, R211K, H221Y, Q278H, T286A, I293V, E297R K13N
>CA38109| codons 1-300
PISPIETVPVKLNPGMDGPKVKQWPLTEEKIKALMEICTELEQDGKISKIGPENPYNTPV
FAIKKKNSTKWRKIVDFRELNKRTQNFWEVQLGIPHPAGLPKNKSVTVLDVGDAYFSIPL
DKDFRKYTAFTIPSINNQTPGIRYQYNVLPQGWKGSPAIFQDSMTKILEPFRKQNPDIVI
YQYVDDLYVASDLEIEQHRTKIEELRQHLWKWGFYTPDKKYQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKHLCKLLRGAKALTEVVPLTREAE

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I84V, L90M L10F R41K, I62V, L63P, I85V, I93L  
>CA38108| codons 1-99
PQITLWQRPFVTIKIGGQLKEALLDTGADDTVLEEMNLPGKWKPKIIGGIGGFIKVRQYD
QVPIEICGHKAIGTVLVGPTPVNVVGRNLMTQLGCTLNF

References
Author Title Citation
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005