<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
CA1446 CA38107 U.S. 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 AZT 104
2 3TC+DDI 8
3 3TC+D4T+IDV 22
4 NFV+NVP+SQV 35
5 None 24
6 3TC+AZT+IDV+RTV 13
7 3TC+AZT+IDV+SQV 32
8 ABC+D4T+EFV+RTV+SQV 104
9 3TC+ABC+EFV+LPV+SQV 19
10 3TC+LPV+TDF 52
11 3TC+LPV+T20+TDF 27

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, L74I, M184V, L210W, T215Y K219R K103N, V106M   K20R, V35M, E44ED, V111I, K122E, E169D, V179I, T200A, H208Y, R211K, K223Q, L228Q, I293V  
>CA38107| codons 1-300
PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALMEICTELEKDGKISKIGPENPYNTPV
FAIKKKNSTKWRKIVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSMTVLDIGDAYFSVPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILDPFRKQNPDIII
YQYVDDLYVGSDLEIGQHRAKIEELRQYLWKWGFYTPDRKHQQEPPFQWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVVPLTEEAE

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, V82T, I84V V11VI, L24I, L33I, L89V L10I, I13V, Q18QH, K20R, E35D, M36I, N37D, R57K, L63P, A71V, I72IV, I93L  
>CA38106| codons 1-99
PQITLWQRPIITVKIGGHLREALIDTGADDTVIEDIDLPGRWKPKIIGGIGGFVKVKQYD
QIPIEICGHKVVGTVLVGPTPTNVIGRNVLTQLGCTLNF

References
Author Title Citation
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005