Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1497 | CA38096 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 152 |
| 2 | AZT+ DDI | 17 |
| 3 | 3TC+ AZT | 17 |
| 4 | AZT+ 3TC+ IDV | 34 |
| 5 | D4T+ DDI+ RTV | 43 |
| 6 | DDI+3TC+NVP+SQV+RTV+D4T | 13 |
| 7 | D4T+DDI+3TC+SQV+RTV | 76 |
| 8 | D4T+DDI+3TC+SQV | 39 |
| 9 | RTV+EFV+APV | 23 |
| 10 | APV+EFV+LPV | 12 |
| 11 | None | 52 |
| 12 | APV+EFV+SQV+TDF | 26 |
| 13 | APV+DDI+EFV+SQV+TDF | 25 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, I84V, L90M | Q58E, G73T | L10I, I13V, L19LQ, K20I, F53FY, K55KR, L63P, H69HR, A71V, I72IV |
| >CA38096| codons 1-99 PQITLWQRPIVTVKIGGQQIEALLDTGADDTVLEEMNLPGRWKPKIIGGIGGYVRVREYD QIPIEICGRKVVTTVLVGPTPVNVIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74V, L210W, T215Y | Y181C, G190A | A98G, K101H, V108VI | K20R, V35I, K43E, V118I, D123E, I135T, D177E, V189VI, T200K, Q207DE, H208Y, R211K, E248D, A272S, K277R, I293V |
| >CA38097| codons 1-300 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALIEICTELEEEGKISKIGPENPYNTPV FAIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPGGLHKKKSVTILDVGDAYFSIPL DKEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIVI CQYMDDLYIASDLEIGQHRKKIEELREYLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPDKDSWTVNDIQKLVGKLNWASQIYSGIKVRQLCKLLRGTKALTEVVPLTEEAE |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |