<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
CA6799 CA38086 U.S. 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 AZT+DDI 74
2 3TC+D4T+IDV 368

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, V82T, I84IV, L90M L10FI, G73GS E35D, N37D, K45KR, L63P, A71V, I93L  
>CA38086| codons 1-99
PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEDMDLPGRWKPRIIGGIGGFIKVRQYD
QIPIEICGHKVISTVLVGPTPTNVIGRNLMTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
D67N, K70R, M184V K219Q     S48T, T69TN, D121Y, K122E, D123DE, E169D, D177E, T200A, Q207K, F214FL, L283I, I293V, P294T, I326V, G333E, Q334N, G335S, R356K, V365VI, T377R, T386I, K390R, T403M, V435L, T470P, Q524E, Q547R  
>CA38087| codons 2-560
ISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKITKIGPENPYNTPVF
AIKKKNSNRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLY
EEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILDPFRKQNPEIVIY
QYVDDLYVGSDLEIGQHRAKIEELRKHLLRWGLTTPDQKHQKEPPFLWMGYELHPDKWTV
QPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLIRGTKALTEVVTLTEEAEL
ELAENREILKEPVHGVYYDPSKDLVAEIQKQENSQWTYQIYQEPFKNLKTGKYAKMRGAH
TNDIKQLTEAVQKIARESIVIWGKIPKFRLPIQKETWEAWWMEYWQATWIPEWEFVNTPP
LVKLWYQLEKEPILGAETFYVDGAANRETKLGKAGYVTDRGRQKVVSLPDTTNQKTELQA
IHLALQDSGLEVNIVTDSQYALGIIQAQPDKSESELVSQIIEELIKKEKVYLAWVPAHKG
IGGNERVDKLVSAGIRKVL

References
Author Title Citation
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005
Rhee, SY Predictive value of HIV-1 genotypic resistance test interpretation algorithms. J Infect Dis, 2009