<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
CA8404 CA38085 U.S. 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 3TC+AZT 9
2 IDV 30
3 3TC+AZT 87
4 D4T+DDI+NVP 208

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, L74LV, V75T, L210W, T215FY K219N Y181C V108I T39A, K43KQ, S68G, T69TI, K104KN, V118VI, D121H, K122E, I135T, D177DE, I178IM, H221Y, V245M, A272P, L283LI, K287KQ, I293V P140T
>CA38085| codons 1-300
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICAELEQEGKISKIGPENPYNTPV
FAIKKKDGIKWRKVTDFRELNKRTQDFWEVQLGIPHPAGLKKKNSVTILDVGDAYFSIPL
HEDFRKYTAFTIPSTNNETTGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEMVI
CQYMDDLYVGSDLEIGQHRTKIEELRQHLWRWGFYTPDNKYQKEPPFLWMGYELHPDKWT
VQPIMLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLIRGTQALTEVVPLTEEAE

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    L10I, V11A, T12TP, Q61QE, I62IV, L63S, I64IM, C67CY, A71V, I72IT, V77I, I93L  
>CA38084| codons 1-99
PQITLWQRPIAPIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVRQYD
EVSMEIYGHKVTGTVLIGPTPVNIIGRNLLTQLGCTLNF

References
Author Title Citation
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005