Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA5177 | CA38076 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+D4T | 57 |
| 2 | 3TC+D4T+IDV | 35 |
| 3 | AZT+DDC+NFV | 26 |
| 4 | AZT+DDI+RTV+SQV | 17 |
| 5 | 3TC+ABC+EFV | 26 |
| 6 | 3TC+D4T+IDV+RTV | 43 |
| 7 | 3TC+ABC+D4T+IDV+RTV | 17 |
| 8 | 3TC+ABC+AZT+EFV | 52 |
| 9 | DDI+LPV+TDF | 31 |
| 10 | APV+DDI+LPV+TDF | 82 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48M, I54V, V82A, L90M | L33F, K43T, F53L, G73S | Q7R, L10V, I15V, K20T, E35D, M36I, R57RK, I62V, L63P, I66F, H69HR, A71V, I72L |
| >CA38076| codons 1-99 PQITLWRRPVVTIKVGGQLTEALLDTGADDTVFEDINLPGRWTPKMIMGIGGLVKVKQYD QVPIEFCGRKVLSTVLVGPTPANIIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K65R, Q151M | A62V, V75I, F77L, F116Y | P4S, S68G, W88WS, V118I, K122E, V245I, E248D, V276T, Q278H, K281R, L283I, T286TA, I293V |
| >CA38077| codons 1-300 PISSIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FVIKRKDGTKWRKLIDLRELNKRTQDFSEVQLGIPHPAGLKKKKSVTVLDVGDAYYSIPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPMGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQPIILPDKDSWTVNDIQKLVGKLNWASQIYAGIKTKHLCRLIRGAKALTEVVPLTEEAE |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |
| Rhee, SY | Predictive Value of HIV-1 Genotypic Resistance Test Interpretation Algorithms. | J Infect Dis, 2009 |