Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA4301 | CA38057 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+AZT+IDV | 47 |
| 2 | D4T+RTV+SQV | 51 |
| 3 | 3TC+D4T+RTV+SQV | 18 |
| 4 | 3TC+D4T+SQV | 56 |
| 5 | 3TC+ABC+AZT+NFV | 55 |
| 6 | 3TC+ABC+AZT+RTV+SQV | 47 |
| 7 | D4T+DDI+NVP | 18 |
| 8 | 3TC+ABC+AZT+LPV+TDF | 60 |
| 9 | 3TC+ATV+NVP+TDF | 16 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74I, M184V, L210W, T215Y | K103KN, Y181C | V108VI | A272P, K277R, T286A, P294T, E297K |
| >CA38057| codons 1-300 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKIVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTILDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI CQYVDDLYVGSDLEIGQHRTKIEELRQHLWRWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKALTEVITLTKEAE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, N88S | N37D, V77I |
| >CA38056| codons 1-99 PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMDLPGRWKPKIIGGIGGFIKVRQYD QILIEICGHKAIGTVLIGPTPVNIIGRSLLTQIGCTLNF |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |