<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
CA5990 CA38037 U.S. 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 AZT 52
2 3TC+AZT+SQV 126
3 3TC+D4T+NFV 90
4 3TC+ABC+APV+D4T+RTV 49
5 3TC+APV+D4T+RTV 130

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, K70R, M184V, L210W, T215Y K219E     K20R, V35K, T39A, K49KQ, T69N, W88C, A98S, K122E, D123E, I135IT, V179I, G196E, T200A, E203K, Q207E, R211RK, F214L, L228H, V245M, A272S, K277R, A288S, E297K  
>CA38037| codons 1-300
PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALKEICAELEKEGKISQIGPENPYNTPV
FAIKKKNSNRWRKLVDFRELNKRTQDFCEVQLGIPHPSGLKKKKSVTVLDVGDAYFSVPL
DEEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIII
YQYVDDLYVGSDLEIEQHRAKIKELREHLWKWGLYTPDEKHQKEPPFHWMGYELHPDKWT
VQPIMLPEKDSWTVNDIQKLVGKLNWASQIYSGIKVRQLCKLLRGTKSLTEVIPLTKEAE

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I50V, L90M L10F, G73A, L89LV I13V, K20V, M36I, I62V, L63P, I64V, T74S  
>CA38036| codons 1-99
PQITLWQRPFVTVKIGGQLVEALLDTGADDTVLEEINLPGRWKPKIIGGVGGFIKVRQYD
QVPVEICGHKAIASVLVGPTPVNIIGRNVMTQIGCTLNF

References
Author Title Citation
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005
Rhee, SY Predictive value of HIV-1 genotypic resistance test interpretation algorithms. J Infect Dis, 2009
Melikian, GL Standardized comparison of the relative impacts of HIV-1 reverse transcriptase (RT) mutations on nucleoside RT inhibitor susceptibility. AAC, 2012