Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA5990 | CA38036 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 52 |
| 2 | 3TC+AZT+SQV | 126 |
| 3 | 3TC+D4T+NFV | 90 |
| 4 | 3TC+ABC+APV+D4T+RTV | 49 |
| 5 | 3TC+APV+D4T+RTV | 130 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I50V, L90M | L10F, G73A, L89LV | I13V, K20V, M36I, I62V, L63P, I64V, T74S |
| >CA38036| codons 1-99 PQITLWQRPFVTVKIGGQLVEALLDTGADDTVLEEINLPGRWKPKIIGGVGGFIKVRQYD QVPVEICGHKAIASVLVGPTPVNIIGRNVMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, M184V, L210W, T215Y | K219E | K20R, V35K, T39A, K49KQ, T69N, W88C, A98S, K122E, D123E, I135IT, V179I, G196E, T200A, E203K, Q207E, R211RK, F214L, L228H, V245M, A272S, K277R, A288S, E297K |
| >CA38037| codons 1-300 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALKEICAELEKEGKISQIGPENPYNTPV FAIKKKNSNRWRKLVDFRELNKRTQDFCEVQLGIPHPSGLKKKKSVTVLDVGDAYFSVPL DEEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIII YQYVDDLYVGSDLEIEQHRAKIKELREHLWKWGLYTPDEKHQKEPPFHWMGYELHPDKWT VQPIMLPEKDSWTVNDIQKLVGKLNWASQIYSGIKVRQLCKLLRGTKSLTEVIPLTKEAE |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |
| Rhee, SY | Predictive Value of HIV-1 Genotypic Resistance Test Interpretation Algorithms. | J Infect Dis, 2009 |