Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1825 | CA38015 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 56 |
| 2 | AZT+DDI | 117 |
| 3 | AZT+DDI+IDV | 9 |
| 4 | 3TC+D4T+NFV | 73 |
| 5 | 3TC+APV+D4T+NFV | 75 |
| 6 | ABC+APV+D4T+NFV | 70 |
| 7 | D4T+DDI+EFV+LPV+TDF | 39 |
| 8 | D4T+TDF+EFV | 38 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L210W, T215Y | K219R | K103N, Y188L | K22N, E28A, K43Q, V118I, K122E, D123N, Q174R, Q207E, A272P, E291D |
| >CA38015| codons 1-299 PISPIETVPVKLKPGMDGPKVNQWPLTAEKIKALVEICTELEQEGKISKIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSIPL DENFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKRNPDIVI YQYMDDLLVGSDLEIGQHRTKIEELREHLWRWGFYTPDRKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTDVIPLTEEA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54M, L90M | L33F, Q58E, G73A | L10I, L19LV, L63P, A71T, I72T, V77I, I93L |
| >CA38014| codons 1-99 PQITLWQRPIVTIKIGGQVKEALLDTGADDTVFEEMNLPGRWKPKLIGGIGGFMKVREYD QIPIEICGHKTTATVLIGPTPVNIIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |