Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA4730 | CA37940 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+AZT+NFV | 13 |
| 2 | 3TC+D4T+NFV | 65 |
| 3 | D4T+DDI+NFV+NVP | 148 |
| 4 | D4T+NFV | 57 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, L90M | L10LI, T12P, K14R, K20I, I62V, L63A, G68D, A71V, T74S, V77I, I93L |
| >CA37940| codons 1-99 PQITLWQRPIVPIRIGGQLIEALLDTGADDTVLEEMNLPGRWKPKIIGGIGGFIKVRQYD QVAIEICDHKVIGSVLIGPTPVNIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| T215F | Y181C | V108I | K11KR, V90VI, K101KQ, K122Q, E169D, D177E, G196E, T200TA, E203K, R211S, V245IMR, K277R, Q278H, I293V, E297K |
| >CA37941| codons 1-300 PISPIETVPVRLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEIQLGIPHPAGLQKKKSVTILDVGDAYFSVPL DQDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILDPFRKQNPEIVI CQYMDDLYVGSDLEIEQHRAKIKELRQHLLSWGFFTPDKKHQKEPPFLWMGYELHPDKWT VQPIRLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVRHLCKLLRGTKALTEVVPLTKEAE |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |
| Rhee, SY | Predictive Value of HIV-1 Genotypic Resistance Test Interpretation Algorithms. | J Infect Dis, 2009 |