Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA5111 | CA37930 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+DDC | 100 |
| 2 | 3TC+AZT | 13 |
| 3 | 3TC+AZT+IDV | 78 |
| 4 | D4T+DDI+NVP | 48 |
| 5 | ABC+RTV+SQV | 70 |
| 6 | ABC+APV+AZT+RTV | 104 |
| 7 | 3TC+AZT+LPV+SQV+TDF | 65 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48L, I54T, V82A, I84V, L90M | L33F, K43T, T74P | L10I, I13V, K20R, E34Q, E35D, M36I, N37S, R41K, I62V, L63P, I64V, A71T, I93L |
| >CA37930| codons 1-99 PQITLWQRPIVTVKIGGQLREALLDTGADDTVFQDISLPGKWTPKMILGIGGFTKVRQYD QVPVEICGHKTIGPVLVGPTPANVIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, L74I, T215F | K219W | Y181C | V179D | P4S, V35I, T39E, V60I, I135IR, A158S, S162C, G196E, T200TA, Q207A, H208HY, R211K, D218E, L228H, V245K, A272P, L283I, I293V |
| >CA37931| codons 1-300 PISSIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICEELEKEGKISKIGPENPYNTPI FAIKKKNSTRWRKIVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSRNNETPGIRYQYNVLPQGWKGSPSIFQCSMTKILEPFRKQNPDIDI CQYMDDLYVGSDLEIEQHRAKIEELRAYLLKWGFFTPEWKHQKEPPFHWMGYELHPDKWT VQPIKLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLIRGTKALTEVVPLTEEAE |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |