Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1869 | CA37925 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+AZT+IDV | 72 |
| 2 | D4T+DLV+RTV+SQV | 9 |
| 3 | 3TC+AZT+IDV | 56 |
| 4 | D4T+EFV+NFV | 37 |
| 5 | ABC+APV+D4T | 18 |
| 6 | None | 50 |
| 7 | 3TC+APV+AZT+EFV+LPV | 24 |
| 8 | 3TC+AZT+EFV+LPV | 18 |
| 9 | None | 61 |
| 10 | 3TC+TDF | 13 |
| 11 | 3TC+ABC+APV+EFV+TDF | 15 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, M184V, T215Y | K101E, Y181C, G190S | A98G | S3C, K20R, V35I, E44D, R83K, V111I, V118I, I142V, K166R, I167V, T200A, I202V, E203D, H208Y, L210S, R211K, H221Y, V245T, E248D, D250E, A272P, K277R, I293V, E297T |
| >CA37925| codons 1-300 PICPIETVPVKLKPGMDGPRVKQWPLTEEKIKALIEICTELEKDGKISKIGPENPYNTPV FAIKKKNSTKWRKVVDFRELNKKTQDFWEVQLGIPHPGGLEKKKSVTVLDIGDAYFSIPL DKDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTRVLEPFRKQNPDIVI CQYVDDLYVSSDLEIGQHRAKVDELRQYLSKWGFYTPDKKYQKEPPFLWMGYELHPDKWT VQPITLPDKESWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVVPLTTEAE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54IV, V82A | L24LI | L10LI, I15V, L19LI, R41K, L63LP, T74S, V77VI |
| >CA37924| codons 1-99 PQITLWQRPIVTIKVGGQIKEALIDTGADDTVLEEMNLPGKWKPKLIGGIGGFVKVRQYD QIPIEICGHKAIGSVLIGPTPANIIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. | J Infect Dis, 2005 |