Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA6437 | CA37914 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+3TC | 108 |
| 2 | 3TC+AZT+SQV | 34 |
| 3 | DDC+DLV+NFV | 134 |
| 4 | ABC+D4T+IDV+RTV | 122 |
| 5 | 3TC+ABC+EFV | 34 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, V75M, M184V, L210W, T215Y | K219N | K101E, Y181C, G190S | A98G | K11KT, V35M, K43N, E44D, V118I, D123E, D177E, E203D, Q207E, H208Y, R211K, L228H, A272P |
| >CA37914| codons 1-300 PISPIETVPVTLKPGMDGPKVKQWPLTEEKIKALMEICTELENDGKISKIGPENPYNTPV FAIKKKDSTKWRKLMDFRELNKRTQDFWEVQLGIPHPGGLEKKKSVTVLDVGDAYFSIPL DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIVI CQYVDDLYVSSDLEIGQHRTKIDELREYLWKWGFYTPDNKHQKEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVIPLTEEAE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, L90M | G73T | L10I, L24F, N37C, K45R, K55R, R57K, L63P, A71V, I72T, V77I, I93L |
| >CA37913| codons 1-99 PQITLWQRPIVTIKIGGQLKEALFDTGADDTVLEEMCLPGRWKPRIIGGIGGFIRVKQYD QIPIEICGHKVTTTVLIGPTPVNIIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |
| Melikian, GL | Standardized comparison of the relative impacts of HIV-1 reverse transcriptase (RT) mutations on nucleoside RT inhibitor susceptibility. | AAC, 2012 |