<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
CA2105 CA37887 U.S. 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 DDC 70
2 D4T 22
3 AZT 11
4 3TC+AZT 12
5 3TC+AZT+IDV 50
6 D4T+DDI+NFV 58
7 D4T+DLV+NFV 34
8 D4T+RTV+SQV 55
9 APV+D4T+SQV 96
10 None 68

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    T12TN, L19LI, R57K, L63P, V77I, I93L  
>CA37887| codons 1-99
PQITLWQRPLVNIKIGGQIKEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVKQYD
QIPIEICGHKAIGTVLIGPTPVNIIGRNLLTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
  T215S     V35VL, T39A, I135L, S162C, R211E, A272S, A288AT, I293V  
>CA37888| codons 1-300
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALLEICAEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DKDFRKYTAFTIPSLNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIVI
YQYMDDLYVGSDLEIGQHRTKIEELRQHLLEWGFSTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYSGIKVKQLCKLLRGTKTLTEVVPLTEEAE

References
Author Title Citation
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005