Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA622 | CA37881 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 18 |
| 2 | AZT+DDC | 4 |
| 3 | AZT+DDI | 13 |
| 4 | 3TC+AZT | 44 |
| 5 | 3TC+D4T+IDV | 22 |
| 6 | D4T+DDI+IDV | 32 |
| 7 | 3TC+D4T+RTV+SQV | 58 |
| 8 | ADV+EFV+RTV+SQV | 104 |
| 9 | ABC+D4T+LPV+TDF | 171 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, L210W, T215Y | V75VA, K219E | F227L | V35I, T39A, E44D, A98AS, L109I, V118I, K122E, V189VI, I202V, H208Y, R211K, D218E, H221HY, L228H, I257L, I293V, E297K |
| >CA37881| codons 1-300 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICAELEKDGKISKIGPENPYNTPV FAIKKKNSTRWRKLADFRELNKRTQDFWEVQLGIPHPSGLKKKKSVTVIDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYIGSDLEIGQHRTKVEELRQYLWKWGFYTPEEKYQKEPPLHWMGYELHPDKWT VQPIVLPEKDSWTVNDLQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVVPLTKEAE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82T, I84V, L90M | L10F, L33F, G73S, L89V | V11L, G16A, L19I, R41K, L63P, A71V, T91S, I93L |
| >CA37880| codons 1-99 PQITLWQRPFLTIKIAGQIKEALLDTGADDTVFEEMNLPGKWKPKIIGGIGGFVKVRQYD QIPIEICGHKVISTVLVGPTPTNVIGRNVMSQLGCTLNF |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |
| Melikian, GL | Standardized comparison of the relative impacts of HIV-1 reverse transcriptase (RT) mutations on nucleoside RT inhibitor susceptibility. | AAC, 2012 |