Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1855 | CA37874 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | Unknown | 52 |
| 2 | D4T | 13 |
| 3 | D4T+DDI+EFV+NFV+Unknown | 28 |
| 4 | ABC+APV+RTV+SQV | 32 |
| 5 | 3TC+APV+RTV+SQV | 74 |
| 6 | 3TC+ABC+D4T+DDI+EFV+LPV+TDF | 35 |
| 7 | 3TC+ABC+APV+D4T+DDI+RTV+TDF | 21 |
| 8 | D4T+DDI+EFV+TDF | 14 |
| 9 | 3TC+D4T+DDI+EFV+T20+TDF | 29 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82A | G73S | L10I, I62V, L63P, A71V, V77I, I93L |
| >CA37874| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFVKVRQYD QVPIEICGHKVISTVLIGPTPANIIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67DN, M184V, L210W, T215Y | K103N, G190GA | P225PH | T39A, E44D, V118I, I142V, K173E, Q207E, R211K, A272P, Q278H, K281R, I293V |
| >CA37875| codons 1-300 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICAELEKDGKISKIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSIPL DKDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFREQNPDIVI YQYVDDLYVASDLEIGQHRTKIEELREHLWKWGFYTPDKKHQKEHPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKHLCRLLRGTKALTEVVPLTEEAE |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |