Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1549 | CA37865 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+DDI | 187 |
| 2 | 3TC+AZT | 67 |
| 3 | 3TC+D4T+IDV | 39 |
| 4 | DDC+DLV+NFV+SQV | 22 |
| 5 | 3TC+D4T+NFV+SQV | 63 |
| 6 | APV+D4T+EFV | 43 |
| 7 | 3TC+APV+DDI+SQV | 15 |
| 8 | 3TC+APV+DDI+DLV+NVP | 25 |
| 9 | APV+DDI+LPV | 42 |
| 10 | D4T+DDI+TDF | 20 |
| 11 | 3TC+D4T+DDI+RTV+SQV+TDF | 17 |
| 12 | 3TC+DDI+IDV+RTV+TDF | 59 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, T69D, L74V, M184V, L210W, T215Y | K219R | K103N, Y181C | V21I, T39A, K43E, E44A, A98S, V111I, V118I, K122E, I135T, K166KR, I178IL, V179IT, E203K, Q207E, H208Y, R211K, K223Q, L228R, Q242L, I257L, A272P, K277R, T286A, I293V |
| >CA37865| codons 1-299 PISPIETVPVKLKPGMDGPKIKQWPLTEEKIKALVEICAELEEAGKISKIGPENPYNTPV FAIKKKDSDKWRKVVDFRELNKRTQDFWEVQLGIPHPSGLKKNKSVTVLDIGDAYFSIPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFRKQNPDLTI CQYVDDLYVGSDLEIGQHRTKIKELREYLWKWGFYTPDRKHQQEPPFRWMGYELHPDKWT VLPIVLPEKDSWTVNDLQKLVGKLNWASQIYPGIKVRQLCKLLRGAKALTEVVPLTEEA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A | L24I, L33F, K43T, G73S | L10I, T12P, I13V, K20R, M36I, K55R, D60E, Q61DN, I62V, L63P, A71AV, I72IT |
| >CA37864| codons 1-99 PQITLWQRPIVPVKIGGQLREALIDTGADDTVFEEINLPGRWTPKLIGGIGGFVRVRQYE NVPIEICGHKVTSTVLVGPTPANIIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |
| Rhee, SY | Predictive Value of HIV-1 Genotypic Resistance Test Interpretation Algorithms. | J Infect Dis, 2009 |
| Melikian, GL | Standardized comparison of the relative impacts of HIV-1 reverse transcriptase (RT) mutations on nucleoside RT inhibitor susceptibility. | AAC, 2012 |