<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
CA7065 CA37857 U.S. 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 AZT+SQV 22
2 AZT+IDV 35
3 3TC+D4T+IDV 191
4 D4T+DDI+EFV 125

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, T69TADN, L74LV, L210W, T215Y   L100I, K103N   K43E, E44A, V60VI, V118I, I135T, D177E, I178M, G196GE, Q207K, R211T, K223KQ, L228R, V245T, A272P, K277R, E297K, K311R, Q334Y, M357V, T403M, T450S, L452A, V467I, L491S, Q509H  
>CA37857| codons 1-560
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEEAGKISKIGPENPYNTPI
FAIKKKDSNKWRKVVDFRELNKRTQDFWEVQLGIPHPAGIKKNKSVTVLDVGDAYFSIPL
DKDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEMVI
YQYMDDLYVGSDLEIEQHRTKIEELRKHLWTWGFYTPDKKHQQEPPFRWMGYELHPDKWT
VQPITLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVIPLTKEAE
LELAENREILREPVHGVYYDPSKDLIAEIQKQGYGQWTYQIYQEPFKNLKTGKYARVRGA
HTNDVKQLTEAVQKIATESIVIWGKTPKFKLPIQKETWEAWWMEYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIVGAETFYVDGAANRESKAGKAGYVTDRGRQKVISLTDTTNQKTELQ
AIHLALQDSGSEVNIVTDSQYALGIIQAHPDKSESELVSQIIEQLIKKEKVYLAWVPAHK
GIGGNEQVDKLVSAGIRKVL

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46L, V82A, L90M   L10I, R41K, K55R, D60E, Q61E, I62V, L63P, A71T, I72R, V77I, I85V, I93L  
>CA37856| codons 1-99
PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMNLPGKWKPKLIGGIGGFIRVRQYE
EVPIEICGHKTRGTVLIGPTPANIVGRNLMTQLGCTLNF

References
Author Title Citation
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005