Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1459 | CA37855 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | DDI | NA |
| 2 | AZT+ 3TC+ SQV | 34 |
| 3 | IDV+ AZT+ 3TC | 17 |
| 4 | NFV+ NVP+ D4T | 21 |
| 5 | NFV+ DLV+ D4T+ 3TC | 21 |
| 6 | 3TC+D4T+DLV | 16 |
| 7 | 3TC+AZT+RTV+SQV | 14 |
| 8 | SQV+ RTV+ EFV+ D4T+ 3TC | 30 |
| 9 | 3TC+ DLV+ D4T+ APV+ ABC | 60 |
| 10 | 3TC+ABC+APV+D4T+RTV | 104 |
| 11 | 3TC+D4T+LPV+TDF | 53 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, K70R, M184V, T215F | D67G, K219Q | K103N | A98G | K20R, T39A, V60I, S68G, T69E, K122E, D123N, I135T, Q174QR, D177EG, I178M, V179I, T200A, D218E, V245K, A272P, A288S, E297K |
| >CA37855| codons 1-300 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICAELEKEGKISKIGPENPYNTPI FAIKKKGGERWRKLVDFRELNKRTQDFWEVQLGIPHPGGLKKNKSVTVLDVGDAYFSVPL DENFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKRNPGMII YQYVDDLYVGSDLEIGQHRAKIEELRQHLLRWGFFTPEQKHQKEPPFLWMGYELHPDKWT VQPIKLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKSLTEVIPLTKEAE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, I54M, I84V, L90M | L33F, G73C | L10I, I13V, L19I, I64V, A71V, V77I, C95L | I66IT |
| >CA37854| codons 1-99 PQITLWQRPIVTVKIGGQIKEALLDTGADDTIFEEMNLPGRWKPKIVGGIGGFMKVRQYD QILVETCGHKVICTVLIGPTPVNVIGRNLMTQIGLTLNF |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |
| Melikian, GL | Standardized comparison of the relative impacts of HIV-1 reverse transcriptase (RT) mutations on nucleoside RT inhibitor susceptibility. | AAC, 2012 |