Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA8000 | CA37850 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | D4T+3TC+IDV | 52 |
| 2 | 3TC+D4T+NFV | 13 |
| 3 | 3TC+D4T+NVP | 243 |
| 4 | None | 17 |
| 5 | 3TC+ABC+EFV+TDF | 32 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K65KR, M184V | A62V, V75VI | K103N, Y181C | V108I, K238T | K32Q, D123E, I135R, K166R, D177E, T200TA, R211RG, F214L, H221Y, V245E, E248Q, A272P, T286TA, I293V |
| >CA37850| codons 1-300 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIQALVEICTEMEKEGKISKIGPENPYNTPV FVIKRKDSTKWRKLIDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTILDVGDAYFSVPL DKEFRKYTAFTIPSRNNETPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFRKQNPEIVI CQYVDDLYVGSDLEIGQHRAKIEELRQHLLGWGLTTPDKKYQKEPPFLWMGYELHPDTWT VQPIELPQKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTEVVPLTEEAE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L10I, K20R, N37ND, R41RK, D60E, I64V, V77I, I85V, I93L |
| >CA37849| codons 1-99 PQITLWQRPIVTIKIGGQLREALLDTGADDTVLEEMDLPGKWKPKMIGGIGGFIKVRQYE QILVEICGHKAIGTVLIGPTPVNIVGRNLLTQLGCTLNF |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |