Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1412 | CA3785 | U.S. | 1998 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 104 |
| 2 | AZT+DDC | 30 |
| 3 | DDI | 74 |
| 4 | 3TC+AZT | 30 |
| 5 | 3TC+AZT+IDV | 30 |
| 6 | 3TC+D4T+NFV | 43 |
| 7 | D4T+DDI+NFV+NVP | 13 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, M184V, L210W, T215Y | K103N, Y181C | K20R, V35M, T39TAEK, E40ED, K43E, K49KR, I50IV, V60I, K64R, R83K, V118I, I135T, G196E, R211K, A288S |
| >CA3785| codons 1-292 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALMEICKDLEEEGKISRVGPENPYNTPI FAIRKKNSTKWRKVVDFRELNKKTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSIPL DKDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI CQYVDDLYVGSDLEIEQHRTKIEELRQHLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKSLTEV |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A | L10V, T12S, L19I, N37S, L63P, A71AV, I93IL |
| >CA3786| codons 1-99 PQITLWQRPVVSIKIGGQIKEALLDTGADDTVLEEMSLPGRWKPKLIGGIGGFVKVRQYD QIPIEICGHKVIGTVLVGPTPANIIGRNLLTQLGCTLNF |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Gonzales, MJ | Extended spectrum of HIV-1 reverse transcriptase mutations in patients receiving multiple nucleoside analog inhibitors. | AIDS, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |