Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA3985 | CA37841 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 78 |
| 2 | AZT+DDC | 86 |
| 3 | 3TC+AZT | 30 |
| 4 | 3TC+AZT+SQV | 13 |
| 5 | 3TC+D4T+RTV | 17 |
| 6 | D4T+DDI+IDV | 26 |
| 7 | AZT+DDI+NFV | 17 |
| 8 | NVP+AZT+DDI+NFV | 13 |
| 9 | DDI+RTV+SQV | 30 |
| 10 | D4T+DDI+RTV+SQV | 13 |
| 11 | D4T+DDI+NFV+SQV | 18 |
| 12 | Unknown | 221 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I84V | L24I, Q58E | L10I, T12P, I13V, A22V, N37S, F53Y, K55R, R57K, D60E, Q61E, I62V, L63P, A71V, I72T, V77VI, I93L |
| >CA37841| codons 1-99 PQITLWQRPIVPVKIGGQLKEVLIDTGADDTVLEEMSLPGRWKPKIIGGIGGYIRVKEYE EVPIEICGHKVTGTVLIGPTPVNVIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, M184V, L210W, T215Y | D67G, K70T | K103KN | K32N, E44D, S68G, V118I, I135K, R211K, A272P, V276T, K277KR, L283I, A288T, I293V |
| >CA37842| codons 1-300 PISPIETVPVKLKPGMDGPKVKQWPLTEEKINALVEICTELEKDGKISKIGPENPYNTPV FAIKKKGGTTWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSIPL DKDFRKYTAFTIPSKNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRTKIEELRQHLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKTRQLCKLIRGTKTLTEVVPLTEEAE |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. | J Infect Dis, 2005 |