Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA4998 | CA37826 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+DDC | 22 |
| 2 | None | 209 |
| 3 | 3TC+AZT+NVP | 26 |
| 4 | None | 39 |
| 5 | 3TC+AZT+EFV | 26 |
| 6 | None | 22 |
| 7 | 3TC+AZT+EFV | 52 |
| 8 | None | 35 |
| 9 | 3TC+AZT+EFV | 48 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| Y188C | V179D | V106VI, K122E, K166KR, Q207E, R211K, K277R, I293V |
| >CA37826| codons 1-300 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSITVLDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFRKQNPDIDI YQYMDDLCVGSDLEIGQHRTKIEELREHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVRQLCKLLRGTKALTEVVPLTEEAE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| Q18E, I62V, L63PS, A71V, I72V, V77I, I93L |
| >CA37825| codons 1-99 PQITLWQRPLVTIKIGGELKEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVRQYD QVSIEICGHKVVGTVLIGPTPVNIIGRNLLTQLGCTLNF |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |
| Melikian, GL | Standardized comparison of the relative impacts of HIV-1 reverse transcriptase (RT) mutations on nucleoside RT inhibitor susceptibility. | AAC, 2012 |