Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA6569 | CA37819 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | D4T+Unknown | 28 |
| 2 | ABC+D4T+Unknown | 9 |
| 3 | 3TC+D4T+Unknown | 24 |
| 4 | 3TC+D4T+LPV | 52 |
| 5 | 3TC+D4T+LPV+TDF | 30 |
| 6 | 3TC+D4T+LPV+TDF | 25 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A | L24I, L33LF | L10I, E35ED, M36L, N37DE, L38W, P39PQ, I62V, L63P, A71V |
| >CA37819| codons 1-99 PQITLWQRPIVTIKIGGQLKEALIDTGADDTVFEDLEWQGRWKPKLIGGIGGFVKVRQYD QVPIEICGHKVIGTVLVGPTPANIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, M184V, L210W, T215Y | K103N | A98AG | E6K, V35KR, T39D, E44ED, V60I, V118I, K122E, I135T, S162C, D177DG, E194ED, G196E, E203K, Q207E, H208HY, R211K, K223KE, L228H, Q242H, T286A, I293V |
| >CA37820| codons 1-300 PISPIKTVPVKLKPGMDGPKVKQWPLTEEKIKALREICDELEKDGKISKIGPENPYNTPI FAIKKKNSDKWRKLVDFRELNKRTQDFWEVQLGIPHPGGLKKNKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPGIVI YQYVDDLYVGSDLDIEQHRTKIKELREYLWKWGFYTPDKKHQEEPPFHWMGYELHPDKWT VHPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTEVVPLTEEAE |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |