Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1485 | CA37813 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 74 |
| 2 | D4T+DDC | 31 |
| 3 | 3TC+AZT | 9 |
| 4 | 3TC+AZT+IDV | 31 |
| 5 | AZT+DDI+IDV | 22 |
| 6 | 3TC+DDI+NFV | 17 |
| 7 | None | 61 |
| 8 | D4T+DDI+SQV | 22 |
| 9 | AZT+EFV+SQV | 48 |
| 10 | ABC+AZT+EFV+SQV | 165 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L10I, K14R, L63A, I72V, V77I, I93L |
| >CA37813| codons 1-99 PQITLWQRPIVTIRIGGQLKEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVRQYD QIAIEICGHKAVGTVLIGPTPVNIIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, K70R, T215F | K219Q | V106A | V179D | K20R, V35M, T39A, E40D, V90I, A98S, K103R, K104N, I135T, S162Y, R211Q, L228H, V245E, T286A, E297K |
| >CA37814| codons 1-300 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALMEICADLEKEGKISKIGPENPYNTPV FAIKKKNSDRWRKLVDFRELNKRTQDFWEIQLGIPHPSGLKKRNSATVLDVGDAYFSVPL DKDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQYSMTKILEPFRKQNPDIDI YQYMDDLYVGSDLEIGQHRTKIEELRQHLLQWGFFTPDQKHQKEPPFHWMGYELHPDKWT VQPIELPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTEVIPLTKEAE |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |
| Rhee, SY | Predictive Value of HIV-1 Genotypic Resistance Test Interpretation Algorithms. | J Infect Dis, 2009 |