<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
CA5350 CA37809 U.S. 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 AZT 213
2 DDI 91
3 D4T 61
4 AZT+DDC+IDV 60
5 3TC+AZT+IDV 17
6 3TC+D4T+NVP 47
7 ABC+RTV+SQV 197

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
I54IV, V82T, I84V, L90M V11VI, L33F, G73S L10V, I13V, I15V, N37ND, K45R, I62IV, L63P, C67CF, A71V  
>CA37809| codons 1-99
PQITLWQRPVITVKVGGQLKEALLDTGADDTVFEEMDLPGRWKPRMIGGIGGFVKVRQYD
QVPIEIFGHKVISTVLVGPTPTNVIGRNLMTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, K70GR, T215F K219Q     V35T, T39A, V60I, T69N, K122E, I135T, T139M, I178L, G196E, E203ED, H208HY  
>CA37810| codons 1-254
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICAELEKEGKISKIGPENPYNTPI
FAIKKKNSNRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSTNNEMPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDLVI
YQYMDDLYVGSDLEIEQHRTKIDELRQYLLRWGFFTPDQKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTV

References
Author Title Citation
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005
Rhee, SY Predictive value of HIV-1 genotypic resistance test interpretation algorithms. J Infect Dis, 2009