Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA2193 | CA37795 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 87 |
| 2 | 3TC+AZT | 70 |
| 3 | 3TC+AZT+NFV | 31 |
| 4 | D4T+IDV+NVP | 58 |
| 5 | 3TC+EFV+NFV+SQV | 28 |
| 6 | 3TC+APV+AZT+EFV | 26 |
| 7 | APV+DDI+EFV+IDV | 74 |
| 8 | 3TC+APV+D4T+LPV | 107 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46MI, V82VA, I84IV | L24LI, Q58QE | L10LI, R57RK, L63C, I64IV, V77VI | T74TR |
| >CA37795| codons 1-99 PQITLWQRPIVTIKIGGQLKEALIDTGADDTVLEEMNLPGRWKPKIIGGIGGFIKVKEYD QICVEICGHKAIGRVLIGPTPANVIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, M184V | K219Q | V60I, T69N, A98S, K122E, D123E, I135IT, I142IV, E194EQ, G196E, D218E, V245E, I293V |
| >CA37796| codons 1-300 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPI FAIKKKNSNRWRKLVDFRELNKRTQDFWEVQLGIPHPSGLKKKKSVTVLDVGDAYFSVPL DEEFRKYTAFTIPSTNNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLQIEQHRTKIEELRQHLLRWGFTTPEQKHQKEPPFLWMGYELHPDKWT VQPIELPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVVPLTEEAE |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |