Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1410 | CA37774 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+DDC+DLV+NFV | 26 |
| 2 | D4T+DLV+NFV | 24 |
| 3 | 3TC+D4T+IDV+NFV | 52 |
| 4 | IDV+NFV | 24 |
| 5 | None | 41 |
| 6 | 3TC+ABC+APV+IDV+RTV | 133 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, M184V | T215V, K219Q | V179D | K20R, V35M, E40EQ, K43N, K103R, V118I, S162A, G196E, Q207E, F214L, L228H, I244V |
| >CA37774| codons 1-247 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALMEICTQLENEGKISKIGPENPYNTPV FAIKKKNSDKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKRKSVTVLDVGDAYFSIPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQASMTKILEPFRKQNPDIDI YQYVDDLYVGSDLEIEQHRTKIEELREHLLRWGLVTPDQKHQKEPPFHWMGYELHPDKWT VQPVVLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L90M | L10I, I62V, L63P, I72L, V77I, I93L |
| >CA37773| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVRQYD QVPIEICGHKALGTVLIGPTPVNIIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |
| Melikian, GL | Standardized comparison of the relative impacts of HIV-1 reverse transcriptase (RT) mutations on nucleoside RT inhibitor susceptibility. | AAC, 2012 |