Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA8086 | CA37772 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+AZT | 22 |
| 2 | 3TC+AZT+IDV | 30 |
| 3 | RTV+SQV | 70 |
| 4 | D4T+NFV+NVP | 22 |
| 5 | D4T+DDI+NFV | 22 |
| 6 | ABC+D4T+NFV | 87 |
| 7 | 3TC+ABC+AZT+NFV | 122 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, K70R, M184V, L210W, T215Y | K219Q | T39A, V60I, V179I, G196K, H208Y, R211K, D218E, L228H, E248D, S251N, A272AP, T286A |
| >CA37772| codons 1-300 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICAELEKEGKISKIGPENPYNTPI FAIKKKNSDRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIII YQYVDDLYVGSDLEIKQHRTKIEELRQYLWKWGFYTPEQKHQKEPPFHWMGYELHPDKWT VQPIVLPDKDNWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTEVIPLTEEAE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A, I84V | L24I | L10I, I13V, G16A, I62V, L63P, A71IV, I72V, V77I, P79D |
| >CA37771| codons 1-99 PQITLWQRPIVTVKIAGQLKEALIDTGADDTVLEEMNLPGRWKPKLIGGIGGFVKVRQYD QVPIEICGHKVVGTVLIGDTPANVIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. | J Infect Dis, 2005 |
| Melikian, GL | Standardized comparison of the relative impacts of HIV-1 reverse transcriptase (RT) mutations on nucleoside RT inhibitor susceptibility. | AAC, 2012 |