Isolate Data
Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
CA8086 | CA37772 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
Order | Regimen | Weeks |
1 | 3TC+AZT | 22 |
2 | 3TC+AZT+IDV | 30 |
3 | RTV+SQV | 70 |
4 | D4T+NFV+NVP | 22 |
5 | D4T+DDI+NFV | 22 |
6 | ABC+D4T+NFV | 87 |
7 | 3TC+ABC+AZT+NFV | 122 |
RT Sequence
NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
M41L, D67N, T69D, K70R, M184V, L210W, T215Y | K219Q | T39A, V60I, V179I, G196K, H208Y, R211K, D218E, L228H, E248D, S251N, A272AP, T286A |
>CA37772| codons 1-300 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICAELEKEGKISKIGPENPYNTPI FAIKKKNSDRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIII YQYVDDLYVGSDLEIKQHRTKIEELRQYLWKWGFYTPEQKHQKEPPFHWMGYELHPDKWT VQPIVLPDKDNWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTEVIPLTEEAE |
Protease Sequence
PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
M46L, I54V, V82A, I84V | L24I | L10I, I13V, G16A, I62V, L63P, A71IV, I72V, V77I, P79D |
>CA37771| codons 1-99 PQITLWQRPIVTVKIAGQLKEALIDTGADDTVLEEMNLPGRWKPKLIGGIGGFVKVRQYD QVPIEICGHKVVGTVLIGDTPANVIGRNLLTQIGCTLNF |
References
Author | Title | Citation |
Rhee, SY | HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. | J Infect Dis, 2005 |
Melikian, GL | Standardized comparison of the relative impacts of HIV-1 reverse transcriptase (RT) mutations on nucleoside RT inhibitor susceptibility. | AAC, 2012 |