Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA5951 | CA37761 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 113 |
| 2 | 3TC+AZT | 9 |
| 3 | 3TC+AZT+IDV | 52 |
| 4 | 3TC+D4T+NVP | 57 |
| 5 | None | 187 |
| 6 | 3TC+ABC+D4T+LPV | 26 |
| 7 | None | 12 |
| 8 | 3TC+ABC+D4T+LPV | 21 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46ML, I47A | L10LI, T12PS, L19I, E35D, M36I, R41RK, Q61QH, L63P, I64V, A71AV, I93L |
| >CA37761| codons 1-99 PQITLWQRPIVSIKIGGQIKEALLDTGADDTILEDINLPGKWKPKLAGGIGGFIKVRQYD HIPVEICGHKVIGTVLVGPTPVNIIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, M184V, L210LW, T215Y | K103KNRS, G190GA | K32N, V35K, T39A, R83K, K173Q, Q174QK, I178IM, E203EK, Q207QR, R211Q, A272P, R284RK, T286A, A288AT |
| >CA37762| codons 1-300 PISPIETVPVKLKPGMDGPKVKQWPLTEEKINALKEICAELEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKKTQDFWEVQLGIPHPAGLKKSKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRQKNPDMVI YQYVDDLYVASDLEIGQHRTKIKELRRHLWQWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLKGAKTLTEVIPLTEEAE |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |