Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA5244 | CA37731 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+AZT | 131 |
| 2 | D4T+EFV+NFV | 70 |
| 3 | 3TC+DDI+IDV+RTV | 69 |
| 4 | None | 52 |
| 5 | 3TC+DDI+IDV+RTV | 72 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74V, M184V, T215Y | P4S, K20R, A98S, K102Q, D123E, K166R, D177E, H208Y, R211K, V245K, K277R, R284K, T286A, E297K |
| >CA37731| codons 1-300 PISSIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPSGLKQKKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFRKQNPEIVI YQYVDDLYVGSDLEIGQHRTKIEELRQYLLKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIKLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVRQLCKLLKGAKALTEVIPLTKEAE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I84V, L90M | L33LI, N88D | L10I, I13V, L63P, A71V, I72IL, V77I, I85V |
| >CA37730| codons 1-99 PQITLWQRPIVTVKIGGQLKEALLDTGADDTVIEEMNLPGRWKPKIIGGIGGFIKVRQYD QIPIEICGHKVLGTVLIGPTPVNVVGRDLMTQIGCTLNF |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |