<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
CA4861 CA37727 U.S. 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 3TC+AZT 35
2 3TC+AZT+IDV 82
3 None 39
4 3TC+D4T+SQV 8
5 D4T+EFV+NFV+NVP 23
6 ABC+APV+DDI 29
7 D4T+RTV+SQV 22
8 ABC+APV+D4T+RTV 96
9 3TC+DDI+EFV+TDF 46

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, K70KR, L74I, M184V, T215F K219Q K103N, V106A F227L V35X, K102KR, D123E, I202V, D218E, V245K, A272P, T286A, I293V, E297K  
>CA37727| codons 1-300
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALXEICTELEKEGKISKIGPENPYNTPV
FAIKKKNSTRWRKIVDFRELNKRTQDFWEVQLGIPHPAGLKRNKSATVLDVGDAYFSVPL
DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYVDDLYVGSDLEIGQHRTKVEELRQHLLRWGFFTPEQKHQKEPPLLWMGYELHPDKWT
VQPIKLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTEVVPLTKEAE

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46L, I54IV, V82VA, I84IV L33LF L10I, I13IV, E35D, N37NDGS, K55KR, R57RK, D60E, I62V, L63T, I64V, E65ED, I66F, A71AV, T91TS, I93IV  
>CA37726| codons 1-98
PQITLWQRPIVTVKIGGQLKEALLDTGADDTVFEDMSLPGRWKPKLIGGIGGFVRVKQYE
QVTVDFCGHKVIGTVLVGPTPANVIGRNLLSQVGCTLN

References
Author Title Citation
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005
Rhee, SY Predictive value of HIV-1 genotypic resistance test interpretation algorithms. J Infect Dis, 2009