Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA6583 | CA37722 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 52 |
| 2 | 3TC+AZT | 9 |
| 3 | 3TC+AZT+SQV | 22 |
| 4 | 3TC+AZT+IDV | 104 |
| 5 | AZT+RTV+SQV | 30 |
| 6 | 3TC+ABC+EFV | 65 |
| 7 | APV+D4T+RTV | 35 |
| 8 | 3TC+AZT+LPV+NVP | 48 |
| 9 | APV+EFV+IDV+TDF | 35 |
| 10 | AZT+EFV+IDV+LPV | 24 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, I54L, L90M | L10F, L33F, G73A | R41T, L63P, A71T, I72R, V77I, I93L |
| >CA37722| codons 1-99 PQITLWQRPFVTIKIGGQLKEALLDTGADDTIFEEMNLPGTWKPKIVGGIGGFLKVRQYD QIPIEICGHKTRATVLIGPTPVNIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74I, L210W, T215Y | V75VA, K219N | K103N, Y181C, G190GA | V108I | K43N, A98S, V118I, D177N, G196E, Q207H, H208HY, R211K, H221Y, L228LH, A272S, T286A, E297K |
| >CA37723| codons 1-304 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELENEGKISKIGPENPYNTPV FAIKKKNSTKWRKIADFRELNKRTQDFWEVQLGIPHPSGLKKNKSVTILDVGDAYFSIPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPNIVI CQYMDDLYVASDLEIEQHRTKIEELRHYLWKWGFYTPDNKYQKEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYSGIKVKQLCKLLRGAKALTEVIPLTKEAE LELA |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |